Benzothiazoles and N-Substituted-a-chloro acetanilides have emerged as structurally novel anti oxidant activity. Therefore various 2-hydrazino benzothiazoles (substituted)-2-amino-(4-substituted)-acetanilides, were synthesized by an aromatic amines treated with chloro acetyl chloride in presence of glacial acetic acid and sodium acetate which gives chloro acetanilides (part-I). The condensation of various substituted chloro acetanilides with 2-hydrazino benzothiazoles, 2-hydrazino benzothiazine and 2-acid hydrazide benzothiazole reacts in the presence of dry 1.4-dioxane and triethyl amine (part-II). The structures of the synthesized compounds (A1-6), (B1-6), (C1-6) were characterized by FTIR, 1HNMR and elemental analysis. All the synthesized compounds were screened for anticonvulsant activity by 4-amino pyridine chemical induction method and phenytoin as standard drug. 4-chloro,4-bromo and 4-methoxy substituted acetanilides showed significant protection against chemical induced convulsions.
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